Hypoxia is a common characteristic of many malignant tumors,
and increased HIF-1α expression predicts the poor prognosis of ovarian cancer.
缺氧是許多惡性腫瘤的共同特徵
Hypoxia is a common characteristic of locally advanced solid tumors
that has been associated with diminished therapeutic response
and, more recently, with malignant progression,
that is, an increasing probability of recurrence, locoregional spread,
and distant metastasis.
缺氧是局部晚期實體瘤的一種常見特徵,與治療反應減少和近期惡性進展相關,
即復發,局部擴散和遠處轉移的可能性增加。
Emerging evidence indicates that the effect of hypoxia on malignant progression
is mediated by a series of hypoxia-induced proteomic
and genomic changes activating angiogenesis, anaerobic metabolism,
and other processes that enable tumor cells to survive
or escape their oxygendeficient environment.
新出現的證據表明,缺氧對惡性進展的影響是由一系列缺氧誘導的蛋白質組和基因組變化
來激活血管生成,無氧代謝以及使腫瘤細胞能夠存活或逃脫其缺氧環境的其他過程介導的。
The function of vascular endothelial growth factor (VEGF) in cancer is not
limited to angiogenesis and vascular permeability.
血管內皮生長因子(VEGF)在癌症中的功能不限於血管生成和血管通透性。
VEGF-mediated signalling occurs in tumour cells, and this signalling contributes
to key aspects of tumorigenesis, including the function of cancer stem cells
and tumour initiation.
VEGF介導的信號傳導發生在腫瘤細胞中,並且這種信號傳導有助於腫瘤發生的關鍵方面,
包括癌症幹細胞的功能和腫瘤起始。
HIF-1α mediates tumor hypoxia to confer a perpetual mesenchymal phenotype
for malignant progression.
HIF-1α介導腫瘤缺氧以賦予惡性進展的永久間質表型。
Stabilization of HIF-1α increased FGF-2 promoter activity
HIF-1α的穩定化增加了FGF-2啟動子活性
由以上可知
HIF-1α及VEGF是主要造成癌腫瘤發生的要素
鋅、維它命C、D、E抑制或下調HIF-1α
鎂、維它命C、D、E降低或下調VEGF
所以
治療癌症的基本營養:鋅、鎂、維它命C、D、E
含維它命C、E的食物:
【三多】維他命C+E口含錠12盒組(60錠*12盒)
【三多】D-α維他命E複方軟膠囊(60粒/盒)
含維它命A+D+C的食物:
【KAWAI 卡歡喜】健康肝油球加C(180粒)
又
細胞週期分析顯示IL-4阻滯G0 + G1期中FGF-2刺激的HUVEC的生長。
這些結果顯示IL-4通過改變細胞週期調控分子的表達來抑制內皮細胞生長。
IL-4導致外周血單核細胞(PBMC)產生VEGF的顯著降低
外源性添加前列腺素E2(PGE2)恢復了IL-4抑制TGF-β誘導VEGF的產生
COX—1合成大部分的PGE2
Cox-1是IL-4依賴性表達
因此
IL-4超重要
能提高IL-4的元素:鋅、維生素A
含維生素A高的食物:辣椒粉、胡蘿蔔、甜椒、鴨蛋黃、鵝蛋黃、枸杞、綠花椰菜、綠茶
相關文章:
全套治療所有癌症的食材參考Part-VII(全套治療所有癌症的食材參考Part-V的修正)